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2007


Febuary 2007


Newcastle University awards large Genotyping project to Geneservice


20 February 2007, Cambridge, (Cambridge, UK) the leading contract research organisation and biological resource supplier today announced that it has been awarded a large genotyping project by The Institute of Human Genetics at Newcastle University on behalf of two National Consortia, for a study into vesicoureteric reflux, a congenital condition which can lead to renal failure. The MRC funded project, to genotype more than 1400 human samples from affected families in the UK and Slovenia was recently subject to an EU tender and Geneservice (GSL) was selected on a range of criteria including: technical specification, price, quality and delivery terms. Financial details of the award were not disclosed.

GSL will initially amplify and quality check the DNA samples using Whole Genome Amplification. Samples will be analysed using high-density Affymetrix GeneChip® Human Mapping arrays to produce genotypes that will then used to perform a whole-genome linkage and association study. The project will begin immediately. The number of samples genotyped in any genome scan is one of the most important factors in determining power. The reduced cost of the Affymetrix high-density arrays coupled with GSL's ISO 9001:2000 certified processes enables more samples to be run, thereby increasing the power of genetic association studies.

Nick Leaves, Operations Director at GSL said ' We're delighted to have been selected as the best Service Provider for this project. The Affymetrix - GSL partnership on this project will deliver an experimental investigation that could only have been dreamed of just a few years ago. In addition, the cost per genotype is very low because of recent price reductions by Affymetrix. This simply means the customer gets more great data for less money.'

Contact:

Nick Leaves

Operations Director
Geneservice
2 Cambridge Science Park
Milton Road
Cambridge
CB4 0FE
Telephone: +44(0)1223 432600
Fax: +44(0)1223 432601
E-mail:
contact

About Geneservice

Geneservice is a worldwide leader in the provision of genomic contract research and the distribution of biological resources for life science research. Since the company's conception, the genomic services and products have been used throughout the academic, industrial, and government research sectors in fields spanning molecular biology, genomics, proteomics, drug discovery and toxicology. Geneservice headquarters are based in Cambridge, UK, visit www.geneservice.co.uk for more information.

NOTE: Affymetrix, the Affymetrix logo and GeneChip® are registered trademarks owned or used by Affymetrix Inc.



Geneservice acquires the DNA Sequencing facility at Biochemistry Department, University of Oxford


8 February 2007, Cambridge, UK - Geneservice today announced that it has acquired the sequencing facility at the Biochemistry Department, University of Oxford. The aim is to create an Oxford based one-stop-shop for genomics contract research, including: DNA sample processing, genotyping, mRNA expression analysis, and microbiological clone management. In particular, the Oxford hub will provide customers throughout Oxford and neighboring regions access to more than 10 years of DNA sequencing experience, and the added benefits of online ordering, comprehensive template recovery, direct sample collection and local customer service support.

The existing DNA sequencing facility, within the Biochemistry Department will become Geneservice's local service hub, with existing university personnel transferring to the company and Simon Mayes moving from the Cambridge operations to lead the new team. Simon will be responsible for integrating Cambridge and Oxford activities, particularly the introduction of extensive quality systems and procedures.

Tom Weaver, Geneservice's CEO, commented "Geneservice is really happy to partner with the premier Biochemistry Department in the UK. We plan to grow the hub and its service offerings, particularly as the Department expands into new premises. The ability to work closely within the university environment is helpful since such close adjacencies allows us to provide a better local customer service and form strategic collaborations for introducing new applications and technology platforms. We also see this as the first of several similar alliances around the UK."

On behalf of the dept of Biochemistry, Prof. David Sherratt, Chair of the DNA Sequencing Management Committee, welcomed the new partnership and the extended services that it will bring.

For more information please see www.geneservice.co.uk

Contact:

Simon Mayes or Nick Leaves

Geneservice
2 Cambridge Science Park
Milton Road
Cambridge
CB4 0FE
Telephone: +44(0)1223 432600
Fax: +44(0)1223 432601
E-mail:
info@geneservice.co.uk




2006


November 2006


Geneservice announces an agreement to distribute biological resources developed by Roswell Park Cancer Institute, including Human and Mouse BAC clones and arrays

29 November 2006: Geneservice (Cambridge, UK) the leading contract research organisation and biological resource supplier today announced the completion of a worldwide license agreement to distribute selected biological resources developed by world renowned Roswell Park Cancer Institute (RPCI).

This new license agreement reinforces Geneservice's position as the leading provider of biological and genomic resources to life science researchers worldwide. Geneservice is one of the largest cDNA and genomic clone distribution companies in the world, and its portfolio of over 12 million clones is constantly growing through license agreements with leading academic institutions.

The Roswell Park Cancer Institute is a cancer research and treatment center located in Buffalo, New York. Founded in 1898 by Dr. Roswell Park, it was the first dedicated medical facility for cancer treatment and research in the United States. The facility is involved in drug development and conducts clinical research for cancer treatment.

Commenting on the importance of the agreement, Tom Weaver, CEO stated, 'This agreement increases open access to the international scientific community to one of the most useful genomic resources ever created. Some of the libraries now available include those used to sequence the human and mouse genomes. These are extremely useful for analyzing and engineering long stretches of DNA for studies in gene regulation, disease mapping and diagnositcs, imprinting, and chromosome dynamics. Such libraries are an important addition to our current product portfolio which also includes important cDNA and RNAi collections"

The Mouse Bac library is available now, for futher information please click here. The Human BAC tilepath library will be available early 2007, therefore please register your interest as soon as possible via the website or by email to info@geneservice.co.uk.

Contact:

Tom Weaver or Andy Walker

Geneservice
2 Cambridge Science Park
Milton Road
Cambridge
CB4 0FE
Telephone: +44(0)1223 432600
Fax: +44(0)1223 432601
E-mail: info@geneservice.co.uk

Notes to Editors:


About Geneservice

Geneservice is a worldwide leader in the provision of genomic contract research and the distribution of biological resources for life science research. Since the company's conception, the genomic services and products have been used throughout the academic, industrial, and government research sectors in fields spanning molecular biology, genomics, proteomics, drug discovery and toxicology. Geneservice headquarters are based in Cambridge, UK, visit www.geneservice.co.uk for more information



Cancer Research Technology Grants Geneservice Distribution Rights of RNA Interference Library Generated at the Netherlands Cancer Institute

London, UK; Cambridge, UK; Amsterdam, Netherlands 27 September 2006: Cancer Research Technology Limited (CRT), the oncology-focused development and commercialisation company, today announce that they have granted Geneservice Limited (Geneservice) a worldwide exclusive licence to distribute the pSUPER RNA interference (RNAi) vector system and pRETROSUPER vector-based short hairpin RNA (shRNA) library generated by researchers at the Netherlands Cancer Institute (NKI).

The pSUPER RNAi vector system, developed by Dr Reuven Agami at the Netherlands Cancer Institute (NKI), enables stable and prolonged inhibition of target gene expression in mammalian cells. The pRETROSUPER vector-based library, consisting of almost 24,000 shRNAs complementary to approximately 8000 genes, was developed by Drs Rene Bernards and Roderick Beijersbergen and their team, also based at the NKI. With an emphasis on oncology-related genes, the library includes a high proportion of candidate drug targets. The library, contains three target sequences per gene, is sequence validated and is available in single well format, thereby facilitating high-throughput target validation in mammalian cells. The pRETROSUPER platform allows introduction of shRNA expression vectors by transfection and retroviral infection.

Contacts:

Dr Roisin NicAmhlaoibh
Business Manager
Cancer Research Technology Limited
+44 207 269 3640


To register your interest in receiving this resource please contact:

Dr Sebastien Allious
Head of Genomic Reagents
Geneservice
+44 1223 432609

Notes to Editors:


About Geneservice
Geneservice was launched in August 2005 following a successful management buyout of the UK Medical Research Council Biological Resource Centre (MRC Geneservice). Geneservice offers access to high quality genomic products and leading contract research for applications in the lifesciences, clinical research and development.
Visit the Geneservice website at www.geneservice.co.uk for more information.

About The Netherlands Cancer Institute
The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) combines a scientific research laboratory with a specialised clinic. It is the only dedicated cancer center in the Netherlands. The primary objective of the NKI-AVL is to make a substantial contribution to combating cancer through a unique interaction of scientific research and clinical application. For more information, please visit www.nki.nl

About Cancer Research Technology
Cancer Research Technology Limited (CRT) is an oncology-focused development and commercialisation company that realises cancer patient benefit from publicly- funded research worldwide. CRT works closely with leading international cancer scientists, their institutes and funding bodies to protect, develop and commercialise oncology-related discoveries. CRT is wholly owned by Cancer Research UK, the largest independent funder of cancer research in the world. Further information about CRT can be found at www.cancertechnology.com


August 2006

Geneservice announces an agreement to distribute selected genomic resources developed by the Wellcome Trust Sanger Institute

1 August 2006: Geneservice (Cambridge, UK) the leading contract research organisation and biological resource supplier today announced the completion of a world wide agreement to distribute selected genomic resources developed by world renowned Wellcome Trust Sanger Institute.

This agreement further strengthens Geneservice's position as the leading genomic resource supplier. These Sanger Institute genomic resources are a significant addition to the reagent portfolio, and will initially add three important libraries to the existing portfolio of over 12 million clones.

All genomic resources will be available to order on-line, via the Geneservice website at http://www.geneservice.co.uk/products/sanger, customers will receive shipments quickly and efficiently. All orders will be backed by the usual exceptional level of customer service and technical support, that customers have come to expect from Geneservice.

Commenting on the importance of the agreement, Tom Weaver, CEO stated, "Geneservice is extremely pleased to be working with Genome Research to market these unique resources, developed at The Sanger Institute. Geneservice originated from the UK Medical Research Council when it was part of Human Genome Program on the Hinxton Genome Campus, so it is exciting to continue working closely with the Sanger. It is our aim to provide a portal for scientists from around the world access to one of the most advanced research programs in the field of genomics. This agreement further re-enforces our commitment to enabling rapid and open access to the highest quality biological tools for life science research."

Contact:

Tom Weaver or Andy Walker

Geneservice
2 Cambridge Science Park
Milton Road
Cambridge
CB4 0FE
Telephone: +44(0)1223 432600
Fax: +44(0)1223 432601
E-mail: contact

About Geneservice
Geneservice was launched in August 2005 following a successful management buyout of the UK Medical Research Council Biological Resource Centre (MRC Geneservice). Geneservice offers access to high quality genomic products and leading contract research for applications in the lifesciences, clinical research and development.


June 2006

Geneservice is selected as one of three preferred suppliers for DNA sequencing to the Medical Research Council

2 June, 2006: Geneservice (Cambridge, UK) the leading contract research provider today announced they have been selected as one of three preferred sequencing service providers for the 35 Medical Research Council (MRC) research sites across the UK.

Geneservice is a privately owned company employing around 30 people with considerable experience in providing genomic contract research services to a wide range of customers both in the UK and abroad. Geneservice is ISO 9001:2000 accredited and offers speedy, high quality data to its sequencing customers

The company has a dedicated and highly skilled DNA sequencing team who will provide an efficient and proven service to the MRC scientists.

Roger Turner, Finance and Commercial Director was pleased that Geneservice had been selected and commented "Geneservice has been providing several of the MRC sites with high quality DNA sequencing services for some years, and we are pleased to have been selected as one of the preferred supplies for the three year contract. We are committed to providing exceptional customer support and the very best sequencing data possible using the latest technology"

Contact:

Roger Turner or Karen Chandler-Smith

Geneservice
2 Cambridge Science Park
Milton Road
Cambridge
CB4 0FE
Telephone: +44(0)1223 432600
Fax: +44(0)1223 432601
E-mail:
contact

About Geneservice
Geneservice was launched in August 2005 following a successful management buyout of the UK Medical Research Council Biological Resource Centre (MRC Geneservice). Geneservice offers access to high quality genomic products and leading contract research for applications in the lifesciences, clinical research and development.



May 2006

Geneservice and DNAFORM enter into exclusive distribution agreements - introducing unique worldwide genomic resources DNAFORM

30 May, 2006: Geneservice (GSL) of Cambridge England, and Kabushiki Kaisha DNAFORM, of Tokyo Japan, today announced exclusive distribution agreements whereby GSL and DNAFORM will jointly distribute FANTOM™ clones developed by RIKEN as well as other unique genomic resources created by leading international research institutions like the NIH. This strategic alliance will give the international life science community access to the world's largest collection of cDNA and genomic clone resources from key model organisms such as human, mouse, rat, primate, C. elegans, Drosophila, and Xenopus.

"We are excited at the prospect of Geneservice partnering with KK DNAFORM for the ability to combine our clone collections with the impressive resources from RIKEN, and expanding our territorial reach into Asia" said Tom Weaver, CEO for Geneservice.

KK DNAFORM, which is actively working on exploiting the RIKEN cDNA library technology, for which it holds exclusive patents, also welcomed this partnership. "We see this strategic alliance as a way to rapidly increase our product portfolio offered in Japan and other Asian countries, and to effectively market our RIKEN FANTOM™ Clones particularly in the EU" stressed Hirohumi Ujita, KK DNAFORM's CEO.

The new alliance was also welcomed by members of the research community, and recognized as a great step forward to increase the awareness about these clone collections in the public domain, and to make them more easily accessible for researches. Professor Yoshihide Hayashizaki, Project Director of the Genome Exploration Research Group at RIKEN, commented "This partnership is really very important to us, and we are hoping that it will give more researches access to our FANTOM™ Clones. Moreover, it is good to know that for the first time a clone provider in Japan will offer all the clones from the international genome projects." Marc Vidal from the DFCI added "The new paradigm of genomics and systems biology requires the creation of genome-wide clone resources. It is essential that international efforts like this take place to make such valuable resources available to the research community, in particular in Asia where a dedicated clone provider was missing."

Contact for more information: Dr Andrew Walker, Resource Development Manager, +44 (0)1223 432600, ajwalker@geneservice.co.uk

Notes to editors About Geneservice: GSL is an innovative genomics-based products and contract research company recently formed from the UK Medical Research Council. Their mission is to provide an archiving and distribution portal for emerging genomic reagents, such as bacterial clones and Human DNA samples, generated by academic groups and consortia internationally. GSL also provides access to state-of-the-art high throughput technologies to academic and commercial clients for the study of gene expression and gene mapping, including disease gene identification, DNA sequencing, extraction and whole genome amplification; micro satellite and SNP genotyping; and RNA expression profiling. Geneservice's one-stop service program for genomics researchers is highly regarded for its quality and customer service. For more information please visit www.geneservice.co.uk

About DNAFORM. DNAFORM was established as a RIKEN Venture to commercialise technologies for the analysis of complex transcriptomes developed as part of the RIKEN Mouse Encyclopaedia Project. DNAFORM's technology platform is based on the patented RIKEN Full-Length cDNA Cloning Approach, which offers effective means for Transcriptome Analysis along with resources for target gene cloning. Expanding on this platform, novel approaches can be offered for Transcriptome Annotation based on 5'-Tag sequencing (CAGE), and the identification of genes regulated on the level of Alternative Splicing (ASSETS). In combination with our flexible Library Construction Program, the DNAFORM technology platform can support research and development in Proteomics, Gene Regulation, Gene Discovery, RNAi, or SNP Analysis. For the promotion of science and the easier availability of DNA clones to the research community, DNAFORM developed further together with RIKEN the concept of the DNABook™, which brings together clones of interest and the related information in a printed format easy to handle, store and use. For more information please visit www.dnaform.jp



May 2006

Geneservice and RNAx GmbH launch PhenoFiler™ - A unique service platform for Gene Discovery and Validation PhenoFiler™"

15 May, 2006: Geneservice Limited (GSL) Cambridge, UK, the leading contract research organisation and biological resource centre and RNAx GmbH (RNAx), Berlin, Germany, a company specialized in RNAi validation technology, announced today the launch of their new mRNA expression PhenoFiler™ service platform. This new platform brings together both companies unique expertise to create a single platform for gene discovery and validation.

Under the terms of the agreement RNAx provides GSL and its customers with in vitro si- and shRNA validation technology to complement GSL's gene expression profiling and network analysis service, and vice versa. PhenoFiler™ will provide researchers with a complete solution for comprehensively profiling tens of thousands of genes and then immediately screening for molecular or cellular phenotypes in a co-ordinated set of experiments.

RNAx has developed a robust automated platform for the customized, rapid and cost effective validation of siRNAs, shRNAs and genetic targets in a broad variety of commonly used cell lines and primary cells, making the screening, selection and functional validation of si- and shRNAs affordable, even at high numbers of targets. Through a number of partnerships with leading European biotech companies, RNAx makes RNAi technology available to many applications during the target discovery and validation process - all the way from gene expression analysis to in vivo validation of more advanced targets.

GSL, a contract research organisation and biological resource centre, recently formed from the UK Medical Research Council that brings with it more than 10 years experience as a national core service laboratory and was one of the first national service providers of mRNA expression analysis in Europe. GSL has also developed novel bioinformatics tools for identifying important relationships between genes, establishing networks based on expression data.

"This agreement gives benefits to both companies: GSL's customers through our one-stop approach will have access to gene silencing technology, and RNAx' customers can take advantage of the full range of GSL's technologies. The customer will not have the need to look for additional providers, and will deal with our two companies as if it was one entity. This will simplify and speed up the service for the customer. Results will be available faster, because our two companies know exactly how to integrate our technologies, commented Joerg Poetzsch, CEO of RNAx.

"We are very pleased to partner with RNAx, as this adds an important new dimension to our contract research capabilities and customer value", said Tom Weaver, CEO of Geneservice.

About Geneservice
Geneservice was launched in August 2005 from the UK Medical Research Council and Human Genome Mapping Project, and offers access to high quality genomic products and leading contract research for applications in the life sciences, clinical research and development. For more information visit
www.geneservice.co.uk

Contact: Tom Weaver, CEO, +44 (0)1223 432602, tweaver@geneservice.co.uk

About RNAx GmbH
RNAx GmbH is an independent functional genomics research and service company based on the application of RNA interference. RNAx's know-how is based on many years of research and development of reliable high-throughput validation technologies using RNA interference at the Max Planck Institute for Infection Biology in Berlin. RNAx offers its customers automated, and thus rapid and cost effective validation of siRNAs, shRNAs and targets. RNAx was founded by scientists of the Max Planck Institute for Infection Biology in Berlin in December 2002, and is financed entirely by its founders and through the generation of revenues from a number of renowned companies like Qiagen, Proligo and major international pharmaceutical companies. www.RNAx.de

Contact: Dr. Joerg Poetzsch, CEO, +49 30 4863 7389, Joerg.Poetzsch@RNAx.de



05 May 2006

Knockout knockdown library

Geneservice are happy to announce the distribution of our forth C. elegans resource in as many months! With over 10 thousand knockdown targets, some of which are unique to this library, the ORF-RNAi library is an ideal resource for large scale-screening and individual knockdown experiments. For more information, please consult the ORF-RNAi website.


20 April 2006

Geneservice's commitment to quality is underlined by ISO 9001:2000 certification

Geneservice (Cambridge, UK) today announced it has received the International Standards Organisation’s (ISO) 9001:2000 certification for the provision of functional genomic products and contract research to academic and commercial research communities worldwide. This follows external validation by Lloyds Register of Quality Assurance (LRQA) a UKAS accredited quality certification body. ISO 9001 is an internationally accepted standard that represents good management practices and aims to ensure that organisations consistently deliver the products or services that meet their clients’ quality requirements.

The achievement of ISO9001:2000 approval reinforces Geneservice’s continued commitment to identify and meet the needs and expectations of its customers and achieve, maintain and improve overall operational performance and capabilities.

Tom Weaver, CEO of Geneservice commented
"This certification further demonstrates Geneservice’s commitment to the highest levels of product and service quality. The staff’s enthusiasm and self motivation was shown clearly by their commitment to the development and application of a Quality Management System at Geneservice"


Contact:
Tom Weaver , CEO
or
Helen Longland, Quality Assurance Manager

Geneservice
2 Cambridge Science Park
Milton Road
Cambridge
CB4 0FE
Telephone: +44(0)1223 432600
Fax: +44(0)1223 432601
Email:
info@geneservice.co.uk


About Geneservice
Geneservice was launched in August 2005 following a successful management buyout of the UK Medical Research Council Biological Resource Centre (MRC Geneservice). Geneservice offers access to high quality genomic products and leading contract research for applications in the lifesciences, clinical research and development. For more information visit www.geneservice.co.uk



March 2006

Wellcome Trust Sanger Institute selects Geneservice as its key contract research partner for Whole Genome Amplification

Cambridge, UK Geneservice, is pleased to announce that the Wellcome Trust Sanger Institute has chosen Geneservice to provide whole genome amplification for circa 25,000 samples from multiple studies including the Wellcome Trust Case Control Consortium (WTCCC), EPIC (obesity), MalariaGen, and the International 1q type 2 diabetes consortium. Large sample collections are essential in investigating the molecular basis of common genetic diseases and susceptibility to pathogens. Expanding the amount of DNA available will allow multiple future experiments on these precious samples that have been collected over many years.

Evaluation of suppliers, was based on a common set of samples tested post-amplification with the Affymetrix Genechip as well as Illumina Golden Gate and Infinium technologies. The selection of Geneservice was based on a combination of responsiveness, performance, quality of service and value for money.

Tom Weaver, CEO of Geneservice commented
"I am delighted that we have been awarded this prestigious project against strong international competition. Working with world class scientific teams and being entrusted to amplify their samples is a tribute to the dedicated Geneservice team"

Panos Deloukas of the Wellcome Trust Sanger Institute added
"We looked for a provider to work closely with us to develop robust protocols for these important projects"


Contact:
Tom Weaver , CEO
or
Roger Turner, Finance and Commercial Director

Geneservice
2 Cambridge Science Park
Milton Road
Cambridge
CB4 0FE
Telephone: +44(0)1223 432600
Fax: +44(0)1223 432601
Email:
info@geneservice.co.uk


About Geneservice
Geneservice was launched in August 2005 following a successful management buyout of the UK Medical Research Council Biological Resource Centre (MRC Geneservice). Geneservice offers access to high quality genomic products and leading contract research for applications in the lifesciences, clinical research and development. For more information visit www.geneservice.co.uk

About Whole Genome Amplification
Whole Genome Amplification is an amplification method using degenerate oligos to produce large amounts of genomic DNA from small amounts of starting material. For more information on Whole Genome Amplification visit http://www.geneservice.co.uk/services/samples/WGA_service.jsp

About Wellcome Trust Sanger Institute
The Sanger Institute is a genome research institute primarily funded by the Wellcome Trust. Our purpose is to further the knowledge of genomes, particularly through large scale sequencing and analysis.



27 February 2006

Geneservice forms strategic alliance with VWR

New specialist service division at VWR to provide customer-facing support for Geneservice, the leading genomic contract research organization.

Cambridge, UK Geneservice, today announced a five-year strategic alliance with VWR for sales representation of the company's leading contract research platforms. Customers in Europe, USA and the UK will now be able to access industry leading genotyping, gene expression and DNA handling capabilities at Geneservice via their local VWR specialist service representative. VWR's sales and marketing operation currently serves over 250,000 customers with an extensive worldwide specialist sales network.

This strategically important agreement, the first since the management buyout of MRC Geneservice in 2005, is further evidence of Geneservice's commitment to providing the very latest discovery contract research platforms to a growing customer base.

Tom Weaver, CEO at Geneservice commented
"Our new alliance with VWR is strategically important for us. It significantly increases our geographical coverage and makes our leading contract research platforms available to more researchers worldwide. We are delighted to have been selected by VWR to be one of the first companies to be included in the VWR BioSciences programme."

The alliance offers an excellent balance and fit between Geneservice's established expertise in genomic contract research and VWR's marketing capabilities, global market strength and representation. Geneservice customers will benefit from the proximity with their local VWR specialist service representative, and will have direct access to leading technology and a team of dedicated, highly qualified scientists with extensive project management experience at Geneservice. With over 10 years experience as a national genomics core laboratory and bioinformatics infrastructure, Geneservice has both the capacity and ambition to move beyond the UK market. Working with VWR will substantially increase Geneservice's exposure by promoting its expert contract research program and customer service to academic, clinical, government, biotech and pharma labs world-wide.

Dr. Weaver also highlighted that
"Working with VWR in setting up this alliance has been terrific, and it has been more like partnering with another small start-up company instead of what is in reality a very large corporation. This has facilitated our ability to move quickly and effectively, and I believe this says a lot about VWR BioSciences innovative management team. Even though selling services will be a new challenge for VWR reps, so far there has been excellent communication with our scientists and shared vision on how to make this venture a success and swiftly grow the business."

VWR International is a global distributor providing a diversified range of products and has recently established VWR Biosciences to provide specialist services, such as those provided by Geneservice, to the bioscience and lifescience Industries. VWR's primary customers work in the pharmaceutical, life science, chemical, technology, food processing and consumer product industry throughout North America and Europe.

Zishan Haroon, General Manager and Global VP of VWR BioSciences commented
"The BioSciences programme extends above and beyond VWR's traditional role by providing research services for our customers' drug discovery and development needs. Establishing a partnership with Geneservice helps accomplish exactly this, offering an industry leader in DNA expression and microarray services to our customers. Geneservice is a highly reputable firm, delivering the highest quality services with the utmost efficiency. Our commitment to excellence ensures that the researcher can have the highest confidence in the value Geneservice provides."


Contact:
Tom Weaver, CEO

or

Roger Turner, Finance and Commercial Director

Geneservice
2 Cambridge Science Park
Milton Road
Cambridge
CB4 0FE
Telephone: +44(0)1223 432600
Fax: +44(0)1223 432601
Email: info@geneservice.co.uk

About Geneservice
Geneservice was launched in August 2005 following a successful management buyout of the UK Medical Research Council Biological Resource Centre (MRC Geneservice). Geneservice offers access to high quality genomic products and leading contract research for applications in the lifesciences, clinical research and development. For more information visit www.geneservice.co.uk




February 2006

FANTOM™ 3 Launch

After the success of the Mouse DNABook™, Geneservice are happy to announce the distribution of the more than 100 thousand FANTOM™ 3 clones. The clones are full-length sequenced, with comprehensive supporting annotation and databases.

Single clones or the complete library are ready for distribution! For more information, please go to our
FANTOM™ 3 webpage.



February 2006

Geneservice Announce the Appointment of Dr Andy Richards as Non-Executive Chairman.

Geneservice (Cambridge, UK), announced today that the Board of Directors has appointed Dr Andy Richards as non-executive Chairman. Dr Richards is a well known Biotechnology entrepreneur having been a founder of several successful Cambridge biotechnology companies including Chiroscience, Arakis, Cambridge Biotechnology and Daniolabs. He holds a number of non-executive director positions including Vectura group plc, Daniolabs, Biowisdom, Babraham Bioscience Technology and Cancer Research Technology (the commercial arm of CR-UK). He is a director of the UK Bioindustry Association and this year was voted both Cambridge Evening News Businessman of the Year as well as one of the Top100 Living Contributors to Biotechnology.

This new appointment follows on from the successful management buyout of Geneservice from the UK MRC in August 2005. On his appointment to the board of Geneservice Dr Richards said,
"Geneservice have already demonstrated that they have real potential to develop into a major provider of specialist high quality contract research and reagents to the life sciences and rapidly growing biotechnology industry. The strong and committed team that led the management buyout have ambitious plans to grow Geneservice and I am delighted to have the opportunity to help them achieve this."

CEO of Geneservice Dr Tom Weaver added,
"We are a young company and our aim was to bring in someone with extensive knowledge of biotechnology and experience with small startup companies. Andy's expertise and networking ability is exactly what we need at this stage of our development, plus he shares our vision to rapidly build up our product and service portfolio. His infectious passion for innovation and getting the most out of our people, operations and business opportunities will add so much to our senior management team."

Notes to editors
Geneservice Limited was launched in August 2005 following a successful management buyout of the UK Medical Research Council Biological Resource Centre (MRC geneservice). GSL offers genomic products and expert contract research for applications in the life sciences and clinical research and development. It provides access to high quality, leading edge genomic products essential for manipulating gene and protein function in the majority of model organisms, including Mouse and Man. GSL also carries out expert technology support on a contract basis. The management team comes with a proven track record at running a National Biological Resource Centre and a super-core laboratory, guaranteeing excellent customer service and access to a "one-stop-shop" for many genomic applications. Our market has international reach with over 900 institutional customers from a database of 21,000 registered users from over 40 countries, and includes: Universities, Charities, Government labs, Biotech and Pharmaceutical companies. These attributes place GSL in a powerful and unique position to fully utilize the commercial potential of emerging genomic research in academia and translate these discoveries into validated, high quality, products and contract research. For more information about Geneservice Limited, its products and research support program log on to the website at
www.geneservice.co.uk.


February 2006

"Sequencing Teams Unite"

Geneservice and the University of Cambridge Department of Genetics are pleased to announce that from the 1st February 2006 the will be some exciting changes to the availability of contract sequencing within the city. The two sequencing teams are joining forces to give customers an improved sequencing and genotyping service at a lower price.

The price for sequencing within the University will drop by 30%. Everything else stays the same: the same personnel, the same instrumentation and the same chemistry – in summary; the same high quality service but for less money! The collaboration promises that turnaround times will be unchanged or improved. Clinics will be held weekly in the department of Genetics to allow customers to discuss any sequencing issues in person. In addition, there will be new services coming on stream as a result of this venture, including: Geneservice’s template recovery process, online ordering system and improved options for sequencing difficult templates.

Chris Maddren, the department of Genetics Sequencing facility manager said:
"We are committed to maintaining the highest quality results in the shortest possible time and I looking forward to working at Geneservice"

Nick Leaves, Operations Director at Geneservice said:
"This is a fantastic example of the type of collaboration we want to do. Chris has made an enormous success of the Genetics Sequencing facility and was an obvious partner for us in expanding the Geneservice Sequencing provision in Cambridge."

For further information please Email Chris Maddren or Nick Leaves at sequencing@geneservice.co.uk or call Geneservice on +44 1223 432600


2005

December 2005

"C. elegans Promoter Library"

A set comprising of more than six thousand C. elegans promoters have been launched! The library format is in 71-microtitre plates, 96-well format. Single clones, full-set or re-arrayed subsets are available from us.

For further information, please go to C. elegans Promoterome Library


November 2005

"Compliment your work with a C. elegans Fosmid Library"

We are happy to announce the launch a comprehensive C. elegans Fosmid library. The N2 based library is the first of it's kind to be distributed, and will be and excellent accompaniment to our every increasing portfolio of resources.

For more information please go to C. elegans Fosmid Library


"C. elegans re-arrays"

Owing to the great success of Julie Ahringer's C. elegans RNAi feeding library, Geneservice are launching 3 subsets of the library. The sub-sets knockdown genes associated with Chromatin, Phosphatase and Transcription factors.

For more information please go to C. elegans RNAi.


September 2005

"Amplify your results with WGA aliquots"

Whole Genome Amplified (WGA) DNA aliquots have been prepared from a diverse range of organisms, to the highest of qualities. Downstream applications may include: PCR, library construction, southern blotting and SNP analysis. If you would like further information please visit our WGA aliquot information page.


September 2005

Launch of Mouse Genome Encyclopaedia

In AD 105, the Chinese court official, Ts´ai Lun, invented papermaking. Since then, this ubiquitous material has continued to play an influential role in many of our civilizations. As we embark into the new Millennium however, we are dominated by the progress that has been made in computer science, thus triggering a complete change in our commercial and private communication behaviour.

Does this mean that the paper era will come to an end? The answer is most definitely "No". This new resource is one of the many reasons why.

Geneservice is happy to announce the distribution of the Mouse Encyclopaedia DNABook™. The book comprises of 60,770 full-length mouse cDNA clones spotted onto paper and bound in an A5 size book. The book is supported by databases for searching individual clones by either location in the book, or gene ID. Furthermore, many functional annotations may also be accessed.

For more information please visit: Mouse Genome Encyclopaedia.


6th June 2005

MRC annouces the buyout of MRC Geneservice


The MRC has given formal approval to a Management Buyout by the management team of MRC geneservice. The new company will be known as Geneservice Limited (Geneservice). MRC geneservice has successfully run as a Resource Centre and Contract Research Organisation within the MRC since October 2001, providing an ever-increasing range of important genomic resources and services to an international customer base. These products and services will continue to be available through Geneservice and new offerings that add value to our customer's research are being actively sourced.
For full press release click here


January 05

"Opening Research Frontiers using a C. jejuni ORF library."


The team at MRC geneservice are delighted to announce the distribution of a Camylobacter jejuni Open Reading Frame (ORF) library. The proteome-scale expression clone set comprises of more than 1,600 ORF's. Jodi Parrish, Russell Finley's laboratory Wayne State University School of Medicine, constructed the library by utilizing the endogenous recombination system of E.coli. MRC geneservice offers the complete clone set of 17 plates 96-well microtitre plates or individual clones, for research purposes only. After expression, affinity purification can be performed on the proteins using either GST or His-tags. There are many post-genomic applications that can be carried out using the library.
More information on the C. jejuni ORF resource


2004

June 2004

TURNING MOLEHILLS INTO MOUNTAINS

MRC geneservice launches new Whole Genome Amplification service

Cambridge, UK - Genome researchers struggling with minute quantities of DNA and degraded samples can breathe a sigh of relief with the launch of MRC geneservice's (MRCg) Whole Genome Amplification service. The new service bolsters MRCg's range of genomic services that include DNA sequencing, SNP genotyping, microsatellites and RNA expression analysis.

With the addition of Whole Genome Amplification (WGA), MRCg will be able to amplify small quantities of precious DNA to provide sufficient quantities for larger scale and multiple projects. MRCg's one-stop service for genomic researchers is setting the standards for quality, turnaround time and price, and WGA customers will also benefit from discounts on subsequent genotyping.

In order to offer the best possible service to genotyping and sample banking clients, MRCg undertook its own comparison of different WGA methods. The result has been an agreement with Molecular Staging Inc (MSI) for MRCg to provide a Whole Genome Amplification service using MSI's proprietary REPLI-g™ technology. 'Technically the MSI system proved superior on our samples to the other systems tested and provides a very effective QC for the end product. This prevents the researcher wasting valuable time and money on genotyping highly degraded samples' said Dr Cheng-Eng Ang, MRC DNA Bank Network Manager, who will be managing the service.

'Partially degraded samples and irreplaceable small quantities of DNA are two of the most common causes of failure in genotyping projects' said Roger Turner, MRCg's CBO. 'Whilst no method can guarantee to rescue highly degraded DNA, MSI's system provides assurance on quality before embarking on further work and provides sufficient quantities for multiple future experiments.'

'The whole genome amplification technology is truly cutting edge and will have a substantial impact on many applications, such as genetic mapping, pathogen identification, forensics and embryonic disease diagnosis. That is why a key milestone for our DNA banking program has been the introduction of effective whole genome amplification for the long term archiving of clinical samples and genotyping. By partnering with MSI we are able to meet our in-house R&D objective and also provide a beneficial contract service open to the research community.' said Tom Weaver, MRC geneservice's CEO.

'We are delighted that MRC geneservice chose our proprietary whole genome amplification technology as the basis for their service offering,' said Dr. Richard Barker, Chairman and CEO of Molecular Staging Inc. 'MRC geneservice joins a long list of prestigious institutes worldwide that have evaluated and chosen MSI's
REPLI-g technology on the basis of performance. Our partnership with MRC geneservice enables us to expand our ability to provide REPLI-g whole genome amplification to an ever growing number of global scientists.'

www.geneservice.co.uk

For more information, please visit WGA service


Editors' notes

MRC geneservice

1. MRC geneservice is a division of the Medical Research Council's Rosalind Franklin Centre for Genomics Research and encourages the use of leading edge technology in genomic research. For more information about MRC geneservice, its products and services log on to the website at www.geneservice.co.uk
2. The Medical Research Council (MRC) is a national organisation funded by the UK tax-payer. Its business is medical research aimed at improving human health. The research it supports and the scientists it trains meet the needs of the health services, the pharmaceutical and other health-related industries and the academic world. MRC has funded work that has led to some of the most significant discoveries and achievements in medicine in the UK. About half of the MRC's expenditure of over £413 million is invested in its 40 Institutes, Units and Centres, where it employs its own research staff. The remaining half goes in the form of grant support and training awards to individuals and teams in universities and medical schools. Web site at: http://www.mrc.ac.uk

Molecular Staging Inc.

Molecular Staging Inc. (MSI) has developed a range of transformational products and services based on its advanced amplification technologies. These products and services include REPLI-g™ whole genome amplification kits and services, a rapid, reliable method of generating unlimited DNA from a few cells to address DNA constraints arising from the rapid growth in the number and variety of genetic tests. MSI has also developed an integrated proteomics chip based discovery service, which offers a powerful new way to identify individual and multiplexed sets of biomarkers to enable new, more effective drugs and diagnostics.
http://www.molecularstaging.com


January 2004

SILENCE OF THE GENES

MRC geneservice launches comprehensive Drosophila RNAi library.

Cambridge, UK - MRC geneservice has announced the launch of their extensive new Drosophila RNA interference (RNAi) library. Encompassing over 90% of the Drosophila genome, researchers can study the function of specific genes through genome-wide screens - a first step in shedding new light on disease processes and possible drug targets.

To read full press release please click here (Adobe PDF format 244K).

To order the Drosophila RNAi please click here.


Available January 2004
If interested in ordering, we advise that you can register and sign the MTA in advance

Drosophila genome RNAi library
A set of 13,600 RNAi constructs are available from MRC geneservice which covers 90% of Drosophila genome. These have been produced as PCR products containing dual T7 promoter sequences, ready for dsRNA synthesis using in vitro transcription protocols. MRC geneservice has partnered with Cyclacel Limited (http://www.cyclacel.com) to make this resource available to the research community; it was made in collaboration with Professor David Glover at the University of Cambridge.

This resource is arrayed in 142 96-well microtitre plates and can be ordered as individual plates or as entire set for genome-wide screen. We are also able to offer dsRNA synthesis service for the plates of your choice. Please send your requests to info@geneservice.co.uk for more details.


2003

Available NOW - 24th November 2003

Subsets of the I.M.A.G.E. Consortium resources

The Mouse Pancreas Genes subset [IRBD, IRBE]
This set of 7000 mouse genes has been rearrayed by the K. Kaestner laboratory (University of Pennsylvania) in 96-well format. Each plate contains clones from one vector only. There are 4 partially-full plates.
This resource is available as a plate set, or as Individual clones.

G PROTEIN COUPLED RECEPTORS (GPCR) Clone set [IRBI.IRBF]
Guthrie cDNA Resource Centre (http://www.guthrie.org/AboutGuthrie/Research/CDNA/), a non-profit organization, provides full-length cDNA clones encoding human signal transduction proteins to the research community. Available as plates or individual clones.

For more details please click here.


20th November 2003

Dear Researcher

MRC geneservice announces new benefits for its Affymetrix clients
Improved service - lower prices!

MRCg is pleased to announce that it is the first UK service provider to own the GeneChip Scanner 3000 enabled for High Resolution Scanning.

This allows us to make our Affymetrix GeneChip service available to you on Affymetrix latest high-density chips ONLY READABLE WITH THE NEW SCANNER. We are therefore able to make significantly more data available to you at our lowest ever prices.

Our price scales have been lowered and simplified, with price breaks for larger experiments. All prices can be seen here. here.

For orders placed and samples received by 31 January 2004 we will offer a further 10% DISCOUNT on these prices.

We will also agree with you a GUARANTEED DELIVERY DATE for your results. If you deliver samples by the agreed time and we fail to deliver your results by the agreed date you will receive a further 10% DISCOUNT!

Examples of the NEW services we are able to offer are:

Data sheets on the above products can be found at http://www.affymetrix.com/products/arrays/index.affx

To discuss your requirements further and place your order please contact us by e-mail microarrays@geneservice.co.uk quoting reference AFFY03.

We look forward to hearing from you.

Yours Sincerely

Roger J L Turner BSc FCA
Finance & Commercial Director


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